Evaluation of the Efficacy of Colistin Therapy with or without Loading Dose in the Treatment of Multi Drug Resistant Gram-negative Bacterial Infections

Aim: Colistin (Col) is an agent used in the treatment of multidrug-resistant gram-negative (MDRGN) bacterial infections. This drug has been administered with a loading dose recent years to provide rapid clinical response and therapeutic blood levels. In our study, we aimed evaluate whether there relationship between efficacy Col treatment, mortality, microbiological clearance during nephrotoxicity, neurotoxicity side effects for MDRGN Material method: this retrospective which included control group, 6-years data was analyzed. Totally, 323 patients who received or without (LD) were study. Patients divided into two groups; I: Col-LD regimen (those hospitalized 2011-2014), II: 2015-2017). Demographic characteristics such as age, gender, cultures, laboratory results, effects, mortality evaluated. Results: A statistically significant found nephrotoxicity. However, it determined that no regimen. Nephrotoxicity be decreased Neurotoxicity observed more frequently (3.7%) Initial final C-reactive protein (CRP) procalcitonin (PCT) levels significantly lower Conclusion: It had effect on neurotoxicity, outcome, but clearance. addition, effective decreasing CRP PCT values.